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Charms are Combo Items in Skitchy swap. They can block or reduce the time and severity of status ailments of an attack or Opponent some of the time. The status ailments are:

Frozen - Leaves immobile, able to be escaped

Cold - Slows movement

Poisoned - Does damage over time

Paralyzed - leaves immobile, unescapable

Spinning - Makes you unable to swap or perform attacks (usually short time anyway)

You can see status ailments/hit effects here